Humulene is a terpene that is commonly found in cannabis cultivars and other plants such as hops, basil, coriander, cloves, sage, black pepper, and balsam fir. It is known for its anti-inflammatory, analgesic, and appetite suppressant properties. Humulene is a monocyclic sesquiterpene. Sesquiterpenes are highly diverse and exhibit a wide range of biological activities. They can act as defensive compounds against herbivores or pathogens, play a role in plant signaling and communication, and contribute to the complex aromas of essential oils. Some sesquiterpenes also possess pharmacological properties and have been studied for their potential therapeutic benefits. Humulene is chemically similar to β-caryophyllene and is also known as alpha humulene or a-humulene. It is responsible for the earthy and hoppy aroma of cannabis strains.
Humulene has been studied for its potential anti-cancer and pain relief properties. Here are some of the therapeutic benefits of humulene in cannabis:
Anti-inflammatory: Humulene has anti-inflammatory properties that can help to alleviate pain and inflammation
Antitumor: Humulene has demonstrated the ability to kill cancer cells, prevent their proliferation, and reduce tumor growth
Antimicrobial: Humulene has antimicrobial properties that can help to kill or repel certain kinds of bacteria
Appetite suppressant: Humulene is an anorectic terpene, which means that it can suppress appetite
It is important to note that humulene does not interact with endocannabinoid receptors, so it cannot get you high. However, terpenes can boost cannabinoid activity and act as a sort of “mimic” of cannabinoids. Humulene can be found in various cannabis strains such as Love Affair, Animal Mints 10, Ice Cream Cake, and LA Kush Cake 2.